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Literature summary extracted from

  • Gosalia, D.N.; Salisbury, C.M.; Ellman, J.A.; Diamond, S.L.
    High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays (2005), Mol. Cell. Proteomics, 4, 626-636.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.21 tissue factor 60fold to 100fold enhancement of amidolytic efficiency Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.21 Ca2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.21 factor IX + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.21 factor X + H2O Homo sapiens
-
 factor Xa
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.21 Homo sapiens
-
-
-
3.4.21.42 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.21 factor IX + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.21 factor X + H2O
-
 Homo sapiens factor Xa
-
 ?
3.4.21.21 N-acetyl-Ala-P3-P2-Lys-7-amido-4-carbamoylmethylcoumarin + H2O P2: Val or Thr, P3: Gln, Arg, Asn or Pro Homo sapiens ?
-
 ?
3.4.21.42 Ac-Ala-P3-P2-P1-7-amino-4-carbamoylmethylcoumarin + H2O a 722-member substrate library with combinations of all proteogenic amino acids at positions P3 and P2 was screened for cleavage, C1s preferred the small polar residues Ser, Ala and Gly at the P2 position and had a broad specificity at P3 position Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.21 human factor VIIa + TF
-
 Homo sapiens
3.4.21.21 tissue factor/factor VIIa complex
-
 Homo sapiens
3.4.21.42 C1s
-
 Homo sapiens
3.4.21.42 complement protease C1s
-
 Homo sapiens